2018
Sirtuin-Pathway Studies
Imai & Guarente
Reviewed NAD+ as a substrate in sirtuin-dependent signaling and aging research.
Lot CBR-NAD-260411-001✓ Verified
About NAD+ Buffered
Nicotinamide Adenine Dinucleotide (NAD+) is a ubiquitous coenzyme central to cellular redox biology, sirtuin-pathway biology, and DNA-repair signaling. Crescent supplies NAD+ in a buffered lyophilized form at 1,000 mg per vial.
Research interest spans mitochondrial biology, sirtuin-pathway studies, PARP-mediated DNA repair, and aging-axis research. The buffered preparation allows reconstitution closer to physiological pH for research applications.
Each lot is independently verified for purity (HPLC) and endotoxin (LAL kinetic chromogenic) before listing.
Identity & Specifications
Sequence
N/A (dinucleotide)
Length
N/A
Formula
C₂₁H₂₇N₇O₁₄P₂
Mol. weight
663.43 g/mol
CAS
53-84-9
PubChem
5892
Purity (HPLC)
≥ 98%
Endotoxin (LAL)
< 0.5 EU/mg
Certificate of Analysis
Lot CBR-NAD-260411-001 — purity and potency independently verified by BTLabs (West Palm Beach, FL); bacterial endotoxin independently verified by Freedom Diagnostics (Franklin, TN). Full parameter results below.
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | FTIR (USP <197A>) | Confirms NAD | Conforms |
| Appearance | Visual (USP <630>) | White powder | White powder |
| Purity | HPLC-UV 280 nm (USP <621>) | ≥ 98.0% | 99.8% |
| Potency | HPLC-UV 280 nm (USP <621>) | 90 – 110% of 1,000 mg | 1,257.7 mg (125.8%)† |
| Endotoxin | LAL (USP <85>) | ≤ 0.05 EU/mL | Pass |
† Measured fill exceeds the labeled potency — the active content is above the 1,000 mg label, not below. The lab confirmed identity and purity; the overfill is documented on the signed certificate.
Download signed certificate →Download Safety Data Sheet →Signed Certificate of Analysis
Independent third-party laboratories: BTLabs · 5730 Corporate Way, Suite 220, West Palm Beach, FL 33407 · (561) 625-0133 and Freedom Diagnostics · Franklin, TN. Three signed pages reproduced below verbatim. Open the original PDF →
Selected References
- Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol, 2014.
- Cantó C, et al. NAD+ metabolism and the control of energy homeostasis. Cell Metab, 2015.
- Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science, 2015.
- Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science, 2015.
- Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol, 2014.
Recent Research Highlights
2016
Mitochondrial Biology
Cantó et al.
Discussed NAD+ flux in mitochondrial energy metabolism and biogenesis.
2014
DNA Repair Pathways
Verdin · Science
Reviewed the role of NAD+ in PARP-mediated DNA repair and cellular longevity.
2008
Aging Research Models
Various
NAD+ levels decline with age across multiple model systems; restoration is widely studied in animal aging research.
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ ESI-MS
LAL
Endotoxin
LAL kinetic
§
Lot-traceable
In COA library
§ Research-Use Compliance
Laboratory research chemical / reagent — not a supplement or drug.
This compound is supplied by Crescent Bioresearch LLC for laboratory research and pre-clinical use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
