2015
Original Identification
Lee et al. · Cell Metab
Identified MOTS-c as a mitochondrial-derived peptide and characterized its metabolic role.
First batch in testingCOA pending
About MOTS-c
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA, identified in 2015 as one of the first known mitochondrial-derived peptides (MDPs). It is implicated as a regulator of metabolic homeostasis and mitochondrial-to-nuclear retrograde signaling.
Research interest centers on AMPK-pathway signaling, insulin-sensitivity studies, and mitochondrial-encoded signaling biology. The peptide is among the most-studied mitochondrial-derived peptides in metabolic research.
Each lot is independently verified for purity (HPLC + ESI-MS) and endotoxin (LAL kinetic chromogenic) before listing.
Identity & Specifications
Sequence
MRWQEMGYIFYPRKLR
Length
16 residues
Formula
C₁₀₀H₁₅₃N₂₇O₂₂S₂
Mol. weight
2174.59 g/mol
CAS
1627580-64-6
PubChem
N/A
Purity (HPLC)
Pending
Endotoxin (LAL)
Pending
Certificate of Analysis
§ First batch in testing — results populate here once the first production lot clears independent third-party verification. The table below shows the acceptance criteria every lot must meet.
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | ESI-MS | Conforms | Pending |
| Purity | HPLC-UV 220 nm | ≥ 98.0% | Pending |
| Endotoxin | LAL kinetic | < 0.5 EU/mg | Pending |
| Water content | Karl Fischer | ≤ 6.0% | Pending |
| Appearance | Visual | White lyophilized cake | Pending |
Selected References
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metab, 2015.
- Kim KH, et al. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus. Cell Metab, 2018.
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator. Nat Commun, 2021.
- Yen K, et al. The emerging role of mitochondrial-derived peptides. Trends Endocrinol Metab, 2020.
- Cobb LJ, et al. Naturally occurring mitochondrial-derived peptides. Aging, 2016.
Recent Research Highlights
2018
AMPK Activation
Kim et al.
Examined MOTS-c effects on AMPK signaling in skeletal muscle research.
2019
Insulin Sensitivity
Various
Multiple groups have investigated MOTS-c effects on glucose uptake and insulin signaling.
2020
Aging Research Models
Reynolds et al.
Examined circulating MOTS-c levels and mitochondrial-encoded peptide biology in aging research.
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ ESI-MS
LAL
Endotoxin
LAL kinetic
§
Lot-traceable
In COA library
§ Research-Use Compliance
Laboratory research chemical / reagent — not a supplement or drug.
This compound is supplied by Crescent Bioresearch LLC for laboratory research and pre-clinical use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
