2009
Anxiolytic-Pathway Research
Kost et al.
Examined Selank effects on anxiety-related behavior in rodent models.
First batch in testingCOA pending
About Selank
Selank is a synthetic heptapeptide developed at the Russian Institute of Molecular Genetics, designed as a stable analog of the endogenous tetrapeptide tuftsin. Its sequence appends a Pro-Gly-Pro tail to the tuftsin core (TKPR) for resistance to enzymatic degradation.
Research interest centers on anxiolytic-pathway models, GABAergic and serotonergic-system interactions, and pre-clinical cognition paradigms. Selank has been the subject of multiple Russian-language publications and Western-translated reviews.
Each lot is independently verified for purity (HPLC + ESI-MS) and endotoxin (LAL kinetic chromogenic) before listing.
Identity & Specifications
Sequence
TKPRPGP
Length
7 residues
Formula
C₃₃H₅₇N₁₁O₉
Mol. weight
751.87 g/mol
CAS
129954-34-3
PubChem
11765631
Purity (HPLC)
Pending
Endotoxin (LAL)
Pending
Certificate of Analysis
§ First batch in testing — results populate here once the first production lot clears independent third-party verification. The table below shows the acceptance criteria every lot must meet.
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | ESI-MS | Conforms | Pending |
| Purity | HPLC-UV 220 nm | ≥ 98.0% | Pending |
| Endotoxin | LAL kinetic | < 0.5 EU/mg | Pending |
| Water content | Karl Fischer | ≤ 6.0% | Pending |
| Appearance | Visual | White lyophilized cake | Pending |
Selected References
- Kozlovskaya MM, et al. Selank and short peptides of the tuftsin family. Neurosci Behav Physiol, 2003.
- Kost NV, et al. Selank as a synthetic anxiolytic peptide. Bull Exp Biol Med, 2001.
- Volkova A, et al. Selank administration affects GABA-receptor expression. Mol Genet Genomic Med, 2016.
- Semenova TP, et al. Selank effects on learning and memory. Eksp Klin Farmakol, 2007.
- Vyunova TV, et al. Peptides of the tuftsin family. Curr Drug Deliv, 2018.
Recent Research Highlights
2014
GABAergic Modulation
Volkova et al.
Investigated effects on GABA-receptor signaling and gene expression in pre-clinical models.
2008
Serotonin System Interaction
Vyunova et al.
Studied Selank-induced changes in serotonergic transmission.
—
Cognition Paradigms
Various
Tested in various pre-clinical models of attention and learning.
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ ESI-MS
LAL
Endotoxin
LAL kinetic
§
Lot-traceable
In COA library
§ Research-Use Compliance
Laboratory research chemical / reagent — not a supplement or drug.
This compound is supplied by Crescent Bioresearch LLC for laboratory research and pre-clinical use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
