1998
α-MSH C-Terminal Activity
Lipton & Catania
Established the anti-inflammatory profile of the C-terminal tripeptide region of α-MSH.
First batch in testingCOA pending
About KPV
KPV is the C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH). The fragment retains anti-inflammatory activity associated with the parent peptide while being significantly smaller and more pharmacokinetically tractable.
Research interest centers on inflammation modulation, melanocortin-receptor signaling, and dermal/intestinal models of inflammation. KPV is one of the most-studied minimal-fragment derivatives of the α-MSH family.
Each lot is independently verified for purity (HPLC + ESI-MS) and endotoxin (LAL kinetic chromogenic) before listing.
Identity & Specifications
Sequence
KPV
Length
3 residues
Formula
C₁₆H₃₀N₄O₄
Mol. weight
342.43 g/mol
CAS
24305-27-9
PubChem
11968928
Purity (HPLC)
Pending
Endotoxin (LAL)
Pending
Certificate of Analysis
§ First batch in testing — results populate here once the first production lot clears independent third-party verification. The table below shows the acceptance criteria every lot must meet.
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | ESI-MS | Conforms | Pending |
| Purity | HPLC-UV 220 nm | ≥ 98.0% | Pending |
| Endotoxin | LAL kinetic | < 0.5 EU/mg | Pending |
| Water content | Karl Fischer | ≤ 6.0% | Pending |
| Appearance | Visual | White lyophilized cake | Pending |
Selected References
- Lipton JM, Catania A. Anti-inflammatory actions of the neuroimmunomodulator α-MSH. Immunol Today, 1997.
- Catania A, et al. α-melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev, 2004.
- Dalmasso G, et al. The KPV tripeptide in IBD models. Gastroenterology, 2008.
- Bigliardi PL, et al. Melanocortins and the skin. Exp Dermatol, 2008.
- Wikberg JES, et al. New aspects on melanocortins and their receptors. Pharmacol Res, 2000.
Recent Research Highlights
2009
Intestinal Inflammation Models
Dalmasso et al.
Examined KPV in models of intestinal epithelial barrier function.
2014
Dermal Inflammation
Bigliardi et al.
Investigated KPV in dermal-inflammation pre-clinical models.
—
Melanocortin-Receptor Studies
Various
Part of broader research on the melanocortin receptor family.
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ ESI-MS
LAL
Endotoxin
LAL kinetic
§
Lot-traceable
In COA library
§ Research-Use Compliance
Laboratory research chemical / reagent — not a supplement or drug.
This compound is supplied by Crescent Bioresearch LLC for laboratory research and pre-clinical use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
