2003
Telomerase-Related Studies
Khavinson et al.
Examined Epithalon in models of telomerase activity in somatic cells.
Lot CBR-E10-260411-001✓ Verified
About Epithalon
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed at the St. Petersburg Institute of Bioregulation and Gerontology as a synthetic analog of the pineal-gland peptide complex Epithalamin.
Research interest centers on telomere biology, pineal-gland physiology, and pre-clinical longevity models. The peptide has been the subject of decades of Russian-language gerontology research with translated reviews available.
Each lot is independently verified for purity (HPLC + ESI-MS) and endotoxin (LAL kinetic chromogenic) before listing.
Identity & Specifications
Sequence
AEDG
Length
4 residues
Formula
C₁₄H₂₂N₄O₉
Mol. weight
390.35 g/mol
CAS
307297-39-8
PubChem
219042
Purity (HPLC)
99.7%
Endotoxin (USP <85>)
13.4 EU/vial · PASS
Certificate of Analysis
Lot CBR-E10-260411-001 — purity, potency, and bacterial endotoxin independently verified by BTLabs (West Palm Beach, FL).
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | FTIR (USP <197A>) | Confirms peptide | Conforms |
| Appearance | Visual (USP <630>) | White powder | White powder |
| Purity | HPLC-UV 220 nm (USP <621>) | ≥ 98.0% | 99.7% |
| Potency | HPLC-UV 220 nm (USP <621>) | 90 – 110% of 10 mg | 10.4 mg (104.0%) |
| Bacterial Endotoxin | Gel-clot (USP <85>) | < 40 EU/vial | 13.4 EU/vial · PASS |
Signed Certificate of Analysis
Independent third-party laboratory: BTLabs · 5730 Corporate Way, Suite 220, West Palm Beach, FL 33407 · (561) 625-0133. Three signed pages reproduced below verbatim. Open the original PDF →
Selected References
- Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity. Bull Exp Biol Med, 2003.
- Anisimov VN, et al. Effect of Epitalon on lifespan and tumor incidence in mice. Mech Ageing Dev, 2003.
- Korkushko OV, et al. Peptide regulation of aging. Bull Exp Biol Med, 2010.
- Khavinson VK. Peptides and Ageing. Neuro Endocrinol Lett, 2002.
- Khavinson VK, Malinin VV. Gerontological aspects of geroprotective peptides. Springer, 2005.
Recent Research Highlights
2007
Pineal Function Models
Anisimov et al.
Studied pineal-axis effects in aging rodent models.
—
Russian Gerontology Literature
Various
Decades of pre-clinical work in Russian gerontology research, with translated reviews.
—
Cellular Senescence Research
Various
Studied in cellular models of senescence and replicative aging.
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ ESI-MS
LAL
Endotoxin
LAL kinetic
§
Lot-traceable
In COA library
§ Research-Use Compliance
Laboratory research chemical / reagent — not a supplement or drug.
This compound is supplied by Crescent Bioresearch LLC for laboratory research and pre-clinical use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
