1977
Original DSIP Isolation
Schoenenberger & Monnier
The original work isolating DSIP from sleep-state cerebral blood and naming the peptide.
First batch in testingCOA pending
About DSIP
Delta-Sleep Inducing Peptide (DSIP) is a 9-residue peptide originally isolated from rabbit cerebral venous blood during electrically induced sleep states. It has accumulated a long research history in models of sleep architecture, stress response, and neuromodulation.
Research interest spans neuroendocrine modulation, EEG-pattern studies, and stress-axis research. DSIP has been studied in a wide range of pre-clinical paradigms despite its mechanism remaining incompletely characterized.
Each lot is independently verified for purity (HPLC + ESI-MS) and endotoxin (LAL kinetic chromogenic) before listing.
Identity & Specifications
Sequence
WAGGDASGE
Length
9 residues
Formula
C₃₅H₄₈N₁₀O₁₅
Mol. weight
848.83 g/mol
CAS
62568-57-4
PubChem
68815
Purity (HPLC)
Pending
Endotoxin (LAL)
Pending
Certificate of Analysis
§ First batch in testing — results populate here once the first production lot clears independent third-party verification. The table below shows the acceptance criteria every lot must meet.
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | ESI-MS | Conforms | Pending |
| Purity | HPLC-UV 220 nm | ≥ 98.0% | Pending |
| Endotoxin | LAL kinetic | < 0.5 EU/mg | Pending |
| Water content | Karl Fischer | ≤ 6.0% | Pending |
| Appearance | Visual | White lyophilized cake | Pending |
Selected References
- Schoenenberger GA, Monnier M. Characterization of a delta-EEG-(sleep)-inducing peptide. PNAS, 1977.
- Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): an update. Peptides, 1986.
- Mendelson WB, et al. Effects of DSIP on sleep in rats. Brain Res, 1984.
- Sudakov KV, et al. DSIP and stress-resistance. Stress, 1995.
- Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide: review. Neurosci Behav Physiol, 2006.
Recent Research Highlights
1984
EEG Pattern Studies
Various
Multiple investigators examined DSIP effects on slow-wave EEG architecture in rodent models.
1995
Stress-Axis Modulation
Sudakov et al.
Examined effects on stress-axis markers in pre-clinical paradigms.
—
Neuromodulation Research
Various
Decades of investigation into DSIP as a tool compound in neuromodulation research.
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ ESI-MS
LAL
Endotoxin
LAL kinetic
§
Lot-traceable
In COA library
§ Research-Use Compliance
Laboratory research chemical / reagent — not a supplement or drug.
This compound is supplied by Crescent Bioresearch LLC for laboratory research and pre-clinical use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
