KLOW

Section 1 Identification

Section 2 Hazard Identification

Classification Basis (Mixture)

This mixture has been classified by the calculation method per GHS Rev. 8 §1.3.2 (Additive Formula and Bridging Principles for Mixtures), based on the concentration and hazard classification of each individual component. No test data on the mixture as a whole are available; component-level classifications are applied additively above the applicable threshold cut-off values.

GHS Classification

• Specific Target Organ Toxicity — Single Exposure (Category 3): Respiratory system
• Skin Sensitization (Category 1): may cause allergic skin reaction

Pictogram

GHS07 — Exclamation Mark (harmonized pictogram for skin sensitization Cat 1, eye irritation Cat 2, and STOT-SE Cat 3)

Signal Word

WARNING

Hazard Statements

• H335 — May cause respiratory irritation.
• H317 — May cause an allergic skin reaction.

Precautionary Statements

• P261 — Avoid breathing dust/fume/gas/mist/vapours/spray.
• P271 — Use only outdoors or in a well-ventilated area.
• P304+P340 — IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312 — Call a POISON CENTER or doctor/physician if you feel unwell.
• P403+P233 — Store in a well-ventilated place. Keep container tightly closed.
• P272 — Contaminated work clothing must not be allowed out of the workplace.
• P280 — Wear protective gloves / protective clothing / eye protection / face protection.
• P302+P352 — IF ON SKIN: Wash with plenty of water and soap.
• P333+P313 — If skin irritation or rash occurs: Get medical advice/attention.

Section 3 Composition / Information on Ingredients

Multi-component preparation

Total peptide content per vial: 80 mg total. Each component individually verified for identity and purity by HPLC per USP <621>. Individual lot-level Certificates of Analysis available at crescentbioresearch.com/coa.

Section 4 First-Aid Measures

Inhalation

Remove person to fresh air and keep at rest in a position comfortable for breathing. If breathing is difficult or symptoms persist, seek medical attention. Show this Safety Data Sheet to attending medical personnel.

Skin Contact

Remove contaminated clothing. Wash affected skin with plenty of soap and water for at least 15 minutes. If skin irritation or rash occurs, seek medical advice. Wash contaminated clothing before reuse.

Eye Contact

Rinse cautiously with lukewarm water for at least 15 minutes, holding eyelids apart. Remove contact lenses if present and easy to do. Continue rinsing. If eye irritation persists, seek medical attention.

Ingestion

Do NOT induce vomiting. Rinse mouth with water. If conscious, give a small amount of water to drink. Seek immediate medical attention. Show this Safety Data Sheet to attending medical personnel.

Most Important Symptoms/Effects

Dust may cause respiratory tract irritation. Skin contact may cause allergic sensitization in susceptible individuals. Eye contact may cause irritation. Systemic effects following occupational exposure have not been characterized.

Indication of Immediate Medical Attention

Treat symptomatically. No specific antidote is known. Contact CHEMTREC (1-800-424-9300) or your regional poison control center for professional guidance.

Section 5 Fire-Fighting Measures

Suitable Extinguishing Media

Water spray, dry chemical, carbon dioxide, or alcohol-resistant foam. Use extinguishing method appropriate to surrounding fire.

Unsuitable Extinguishing Media

None known.

Specific Hazards Arising from the Chemical

The compound is not flammable under normal conditions. Under fire conditions, thermal decomposition may release toxic and irritating gases including oxides of carbon, nitrogen, and (where applicable) sulfur.

Special Protective Equipment for Firefighters

Wear self-contained breathing apparatus (SCBA) with full protective clothing. Standard firefighter turnout gear is appropriate.

Section 6 Accidental Release Measures

Personal Precautions

Evacuate non-essential personnel from the affected area. Wear appropriate personal protective equipment (see Section 8). Ensure adequate ventilation. Avoid generating dust when handling spilled material.

Environmental Precautions

Prevent release to sewers, drains, or waterways. Contain any liquid releases with suitable absorbent material.

Methods for Containment and Cleanup

Carefully collect spilled powder using a HEPA-filtered vacuum, damp cloth, or suitable dust-suppressing technique. Do not sweep dry. Place collected material and contaminated cleanup materials in a sealed, labeled container for disposal in accordance with Section 13 and applicable regulations. Wash the affected area with water after collection.

Section 7 Handling and Storage

Precautions for Safe Handling

Handle only in a well-ventilated laboratory environment. Use in a certified biosafety cabinet or chemical fume hood when weighing, reconstituting, or otherwise manipulating the material to prevent inhalation of dust. Avoid contact with skin, eyes, and mucous membranes. Wear appropriate personal protective equipment as described in Section 8. Do not eat, drink, or smoke while handling. Wash hands thoroughly after handling.

Conditions for Safe Storage

Store sealed at −20 °C. Reconstituted material 2–8 °C, use within 30 days. Keep container tightly sealed to prevent moisture ingress. Protect from light where noted. Store away from strong oxidizers, incompatible chemicals, and heat sources.

Incompatibilities

Strong oxidizing agents, strong acids, strong bases. Peptide integrity may be compromised by prolonged exposure to heat, moisture, oxidative conditions, or reactive electrophiles.

Reconstitution

If used, reconstitute using appropriate laboratory-grade solvent for the intended research application (typically bacteriostatic water, sterile water for injection USP, or 0.9% saline for downstream research use). Solutions should be prepared aseptically under a laminar-flow hood. Reconstituted material should be stored at 2–8 °C and used within 30 days of reconstitution unless otherwise indicated by stability data.

Section 8 Exposure Controls / Personal Protection

Occupational Exposure Limits

No OSHA Permissible Exposure Limits (PELs), ACGIH Threshold Limit Values (TLVs), or NIOSH Recommended Exposure Limits (RELs) have been established for this compound. Handle as a compound of low-to-moderate toxicological hazard requiring standard laboratory precautions.

Engineering Controls

Use in a certified chemical fume hood or biosafety cabinet with adequate face velocity when weighing, transferring, or reconstituting the compound. General laboratory ventilation of at least 6–10 air changes per hour is recommended. Eyewash and safety shower should be available in the immediate work area.

Personal Protective Equipment (PPE)

• Respiratory protection: When engineering controls are inadequate to prevent inhalation, use a NIOSH-approved N95 or P100 particulate respirator. Fit-testing per 29 CFR 1910.134 is required.
• Eye protection: ANSI Z87.1-compliant chemical splash goggles. A face shield is recommended for weighing operations.
• Hand protection: Nitrile examination gloves (minimum 4-mil thickness). Change gloves immediately if contamination occurs. Use double-gloving for extended handling.
• Body protection: Standard laboratory coat with sleeves buttoned. Closed-toe shoes required. Change contaminated clothing promptly.

General Hygiene

Do not eat, drink, smoke, or apply cosmetics in the work area. Wash hands and exposed skin thoroughly after handling. Contaminated work clothing should not be allowed out of the workplace.

Section 9 Physical and Chemical Properties

Section 10 Stability and Reactivity

Reactivity

Not reactive under normal handling and storage conditions.

Chemical Stability

Stable at recommended storage conditions. Reconstituted material may exhibit reduced stability over time due to peptide degradation.

Possibility of Hazardous Reactions

None known under normal conditions of use and storage. Hazardous polymerization does not occur.

Conditions to Avoid

Temperature above recommended storage. Moisture and humidity. Direct sunlight and UV exposure. Oxidizing atmospheres.

Incompatible Materials

Strong oxidizers, strong acids and bases, reactive electrophiles.

Hazardous Decomposition Products

Under fire or extreme thermal conditions: oxides of carbon, oxides of nitrogen, oxides of sulfur (where applicable), and other volatile decomposition products characteristic of peptide combustion.

Section 11 Toxicological Information

Likely Routes of Exposure

Inhalation of dust during weighing or reconstitution. Skin or eye contact through direct handling. Ingestion (accidental) via hand-to-mouth contact if hand hygiene is inadequate.

Acute Toxicity

Component-specific acute oral, dermal, and inhalation LD₅₀ values have not been fully characterized for this compound in its research-grade lyophilized form. Handle as a compound of low-to-moderate acute toxicity.

Skin Corrosion / Irritation

May cause mild skin irritation on prolonged or repeated contact. Not classified as a corrosive.

Serious Eye Damage / Irritation

May cause eye irritation on direct contact. Not classified as a serious eye damage hazard.

Respiratory or Skin Sensitization

May cause allergic skin reaction (Category 1 sensitizer) in susceptible individuals following prolonged or repeated dermal exposure. Respiratory sensitization potential has not been characterized.

Germ Cell Mutagenicity

No data available. Handle as a substance of unknown mutagenic potential.

Carcinogenicity

Not listed as a carcinogen by IARC, NTP, or OSHA. No carcinogenicity data available.

Reproductive Toxicity

No data available. Handle as a substance of unknown reproductive toxicity potential.

Specific Target Organ Toxicity — Single Exposure (STOT-SE)

Category 3: May cause respiratory irritation from inhalation of dust.

Specific Target Organ Toxicity — Repeated Exposure (STOT-RE)

Not established for this compound. Handle as a substance of unknown chronic toxicity potential.

Aspiration Hazard

Not applicable (solid).

Additional Notes

The pharmacological, toxicological, and stability properties of this compound in humans and animals have not been fully studied. It must be handled only by personnel trained in laboratory safety practices, and no self-administration or human/veterinary administration is permitted or supported.

Section 12 Ecological Information

Ecotoxicity

This compound has not been evaluated for environmental fate and effects. Avoid release to the environment as a precautionary measure.

Persistence and Degradability

No specific data available. Peptides are generally biodegradable under normal environmental conditions.

Bioaccumulative Potential

Not expected to bioaccumulate based on molecular structure.

Mobility in Soil

No data available.

Other Adverse Effects

None known.

Section 13 Disposal Considerations

Waste Treatment Methods

Dispose of contents and container in accordance with applicable federal, state, and local regulations governing research chemical waste. In the United States, this compound is not currently listed as a RCRA hazardous waste (40 CFR Part 261). Nevertheless, consult your institution's environmental health and safety (EH&S) office and licensed hazardous waste disposal contractor to determine appropriate disposal method for your jurisdiction and quantity.

Contaminated Packaging

Empty vials and packaging should be triple-rinsed with water before disposal, or handled as chemical waste according to institutional policy.

Prohibitions

Do not discharge into drains, sewers, waterways, or the environment. Do not incinerate empty containers without appropriate authorization.

Section 14 Transport Information

Section 15 Regulatory Information

US Federal Regulations

TSCA (Toxic Substances Control Act): Research and development quantities. This substance is manufactured or imported for research and development use only and is exempt from full TSCA inventory reporting under 40 CFR 720.36.

CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act): No reportable quantity established.

SARA Title III (Superfund Amendments and Reauthorization Act): Not listed under Sections 302 (Extremely Hazardous Substances), 311/312 (Hazard Categories for SDS), or 313 (Toxic Chemical Release Inventory).

OSHA HCS (29 CFR 1910.1200): This SDS conforms to the OSHA Hazard Communication Standard.

FDA: This compound is a research chemical and is not approved by the U.S. Food and Drug Administration for human, veterinary, diagnostic, or therapeutic use. It is sold for laboratory research and pre-clinical use only.

State Right-to-Know

California Proposition 65 (Prop 65): This compound is not currently listed on the California Prop 65 list. Users in California should independently verify the current status of any specific compound at oehha.ca.gov/proposition-65.

Massachusetts, New Jersey, Pennsylvania Right-to-Know: No specific listings.

International

Canada WHMIS 2015: Classified in accordance with GHS as applicable.

EU CLP (Regulation (EC) No 1272/2008): Classified in accordance with GHS as applicable. Note: this product is not intended for export outside the United States by Crescent Bioresearch.

Product-Specific Note

Compound: KLOW (CAS N/A (multi-component)) — Regulatory status may vary by jurisdiction. Users are responsible for verifying local regulatory obligations.

Section 16 Other Information

Preparation Details

GHS Hazard Statements Legend (for statements referenced above)

• H317 — May cause an allergic skin reaction
• H319 — Causes serious eye irritation
• H335 — May cause respiratory irritation
• H411 — Toxic to aquatic life with long lasting effects

Abbreviations Used

• ACGIH — American Conference of Governmental Industrial Hygienists
• CAS — Chemical Abstracts Service
• CFR — Code of Federal Regulations
• DOT — Department of Transportation
• FDA — Food and Drug Administration
• GHS — Globally Harmonized System of Classification and Labelling of Chemicals
• HCS — Hazard Communication Standard (OSHA)
• HEPA — High-Efficiency Particulate Air
• HPLC — High-Performance Liquid Chromatography
• IATA — International Air Transport Association
• IMDG — International Maritime Dangerous Goods
• NIOSH — National Institute for Occupational Safety and Health
• OSHA — Occupational Safety and Health Administration
• PEL — Permissible Exposure Limit (OSHA)
• PPE — Personal Protective Equipment
• REL — Recommended Exposure Limit (NIOSH)
• SDS — Safety Data Sheet
• STOT — Specific Target Organ Toxicity
• TLV — Threshold Limit Value (ACGIH)
• TSCA — Toxic Substances Control Act

Disclaimer

The information contained in this Safety Data Sheet is provided in good faith and is believed accurate as of the issue date. No warranty, express or implied, is given regarding the completeness or accuracy of the information for any specific application. The purchaser and end user are responsible for determining the suitability and safety of the material for their intended research use and for complying with all applicable regulations. Crescent Bioresearch, LLC assumes no liability for any injury or damage arising from use of, or exposure to, this material outside the recommendations of this Safety Data Sheet.