2006
GHRH Analog Pharmacokinetics
Teichman et al. · J Clin Endocrinol Metab
Characterized the half-life and GH-pulse response of GHRH analog families in clinical research.
First batch in testingCOA pending
About CJC-1295 (No DAC)
CJC-1295 (no DAC), also referred to in the literature as Modified GRF 1-29, is a 29-residue analog of human growth-hormone-releasing hormone (GHRH 1-29) carrying four amino-acid substitutions designed to confer enzymatic stability.
Research interest centers on GHRH-receptor signaling and the kinetics of GH-releasing factor analogues. The peptide has been investigated in pre-clinical models of growth-hormone insufficiency and as a comparator to native GHRH 1-29.
Each lot is independently verified for purity (HPLC + ESI-MS) and endotoxin (LAL kinetic chromogenic) before listing.
Identity & Specifications
Sequence
YADAIFTQSYRKVLAQLSARKLLQDIMSR
Length
29 residues
Formula
C₁₅₂H₂₅₂N₄₄O₄₂
Mol. weight
3367.94 g/mol
CAS
863288-34-0
PubChem
57396696
Purity (HPLC)
Pending
Endotoxin (LAL)
Pending
Certificate of Analysis
§ First batch in testing — results populate here once the first production lot clears independent third-party verification. The table below shows the acceptance criteria every lot must meet.
| Parameter | Method | Spec | Result |
|---|---|---|---|
| Identity | ESI-MS | Conforms | Pending |
| Purity | HPLC-UV 220 nm | ≥ 98.0% | Pending |
| Endotoxin | LAL kinetic | < 0.5 EU/mg | Pending |
| Water content | Karl Fischer | ≤ 6.0% | Pending |
| Appearance | Visual | White lyophilized cake | Pending |
Selected References
- Teichman SL, et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295. J Clin Endocrinol Metab, 2006.
- Mayo KE, et al. Growth hormone-releasing hormone: synthesis and signaling. Recent Prog Horm Res, 1995.
- Frohman LA, Kineman RD. Growth hormone-releasing hormone and pituitary development. Endocrinology, 1999.
- Veldhuis JD, et al. Pulsatile GH secretion: theoretical perspectives. Endocr Rev, 1991.
- Khorram O, et al. GHRH analogs: structure-activity relationships. Trends Endocrinol Metab, 1997.
Recent Research Highlights
2005
GHRH Receptor Signaling
Mayo et al.
Reviewed GHRH-receptor mechanisms and analogue design.
—
Comparator Studies
Various
Used as a comparator molecule in studies of native GHRH 1-29 and longer-acting derivatives.
—
Combination Research
Various
Often paired with GHRP analogs in models of synergistic GH release.
⊕
3rd Party Tested
Independent lab
≥98%
HPLC Purity
+ ESI-MS
LAL
Endotoxin
LAL kinetic
§
Lot-traceable
In COA library
§ Research-Use Compliance
Laboratory research chemical / reagent — not a supplement or drug.
This compound is supplied by Crescent Bioresearch LLC for laboratory research and pre-clinical use only. It is not a drug, dietary supplement, food, or cosmetic, and has not been approved by the U.S. Food and Drug Administration for human or veterinary administration, diagnosis, treatment, or prevention of any condition.
The pharmacological, toxicological, and stability properties of this compound have not been fully studied. It must therefore be handled only by personnel trained in laboratory safety practices.
The purchaser bears sole responsibility for ensuring that all handling, storage, and intended use comply with applicable local, state, and federal regulations. Full terms are set out in the RUO Disclaimer and Terms of Service.
